Wasco (formerly, Dewey and Deweyville) is a city in the San Joaquin Valley, in Kern County, California, United States. Wasco is located 24 miles northwest of Bakersfield, at n elevation of 328 feet. The population was 25,545 at the 2010 census, up from 21,263 at the 2000 census. Wasco is the headquarters of the Tejon Indian Tribe of California, a federally recognized tribe of Kitanemuk, Yokuts, and Chumash Indigenous people of California.

The Amtrak service, the San Joaquins, stops at the Wasco station, which has one platform next to the single track; the station building was demolished in 2021. Being on the route of the high speed rail project without a stop, Wasco city officials have expressed concerns that the Amtrak service might be discontinued. As of August 2020, no decision has been announced